Human Umbilical Cord Mesenchymal Stem Cells Over Platelet Rich Fibrin Scaffold for Mandibular Cartilage Defects Regenerative Medicine
نویسندگان
چکیده
Objective: To evaluate the regeneration of mandibular cartilage defect after implantation human umbilical cord mesenchymal stem cells (hUCMSC) over platelet rich fibrin (PRF) as scaffold. Material and Methods: 20 male Wistar rats were randomly divided into four experimental groups consisting of: a control group featuring untreated defects (C), whose implanted with hUCMSC (E1), PRF (E2), scaffold (E3). The subjects sacrificed six weeks observation for immunohistochemical examination in order to expression Ki67, Sox9, FGF 18, type 2 collagen, aggrecan, addition histology chondrocyte number thickness. Data was analyzed univariate analysis (ANOVA). Results: proved capable regenerating through chondrosis counts, significantly higher E3. Conclusion: Human defect.
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ژورنال
عنوان ژورنال: Brazilian Research in Pediatric Dentistry and Integrated Clinic
سال: 2021
ISSN: ['1983-4632', '1519-0501']
DOI: https://doi.org/10.1590/pboci.2021.020